TBH, it's a new squad under a new coach, and most (not all) of the major issues seemed to be communication / familiarity ones. There was also some promising stuff out there - with the ball, we had some ambition (less than I'd like, but more than we've seen recently); and these things take time to bed down.
I'd be loathe to make many changes at all at this stage - Week 3 is the time to make major changes, after the rest week.
I'd stick to players who were (or were considered to be) unavailable, and maybe the odd bench/starter swap.
So Jack Willis, and any of the injured players returning to fitness - and I don't think anyone is expected this week.
So Willis and Watson to start, probably for BCurry and OHC.
Yes, I want rid of Youngs and Farrell (and Mako), but absent viable alternatives, I'd stick with them - despite having called for their heads many times over the last 3 (well, 6) years.
TBH, BCurry and OHC deserve a chance to put right what went wrong; but they were also a bit... rabbit in the headlights... shellshocked... They're the most likely to need a bit of time to process WTF just happened. They're also the ones with superior, more experienced options waiting in the wings.