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Gloucester v London Irish (Sat)</div>
Welsh number eight Gareth Delve could return to the Gloucester squad after six months out with a knee injury.
But flanker Peter Buxton (ankle) is ruled out, while England centre Mike Tindall (dead leg) remains a doubt.
For the visitors London Irish, Delon Armitage starts his first Premiership match in a month at full-back, with Peter Hewat moving to fly-half.
Bob Casey and Nick Kennedy are paired together in the second row for the first time in 10 weeks.
Gloucester head coach Dean Ryan told BBC Points West: "Success in the EDF Cup has bought the fixture here and we haven't got any choice in that. At the moment, because of injuries, we could probably do without it, but that's life, we've got to get on with it and try and get a result.
"We're getting more and more injuries the more we play at the moment and we've got 12 or 13 frontline players who are unavailable so we're getting pretty low on numbers, but we'll get enough right this week and hopefully we'll go into the weekend in a positive mood.
"Just for us to get a result at the moment would be a result, and to be top of the league would certainly lift spirits."
Gloucester: Willie Walker; Iain Balshaw, Henry Trinder, Anthony Allen, James Simpson-Daniel; Olly Barkley, Rory Lawson; Alasdair Dickinson, Olivier Azam (captain), Greg Somerville, Adam Eustace, Alex Brown, Alasdair Strokosch, Apo Satala, Gareth Delve.
Replacements: Andy ***terrell, Nick Wood, Marco Bortolami, Andy Hazell, Dave Lewis, Ryan Lamb, Mark Foster.
London Irish: Delon Armitage; Topsy Ojo, Elvis Seveali'i, Seilala Mapusua, Adam Thompstone; Peter Hewat, Paul Hodgson; Clarke Dermody, David Paice, Tonga Lea'aetoa, Nick Kennedy, Bob Casey (captain), Richard Thorpe, Declan Danaher, Chris Hala'Ufia.
Replacements: Alex Corbisiero, Danie Coetzee, Richard Skuse, James Hudson, Gary Johnson, Alfredo Lalanne, Mike Catt.
From: BBC Sport
Gloucester v London Irish (Sat)</div>
Welsh number eight Gareth Delve could return to the Gloucester squad after six months out with a knee injury.
But flanker Peter Buxton (ankle) is ruled out, while England centre Mike Tindall (dead leg) remains a doubt.
For the visitors London Irish, Delon Armitage starts his first Premiership match in a month at full-back, with Peter Hewat moving to fly-half.
Bob Casey and Nick Kennedy are paired together in the second row for the first time in 10 weeks.
Gloucester head coach Dean Ryan told BBC Points West: "Success in the EDF Cup has bought the fixture here and we haven't got any choice in that. At the moment, because of injuries, we could probably do without it, but that's life, we've got to get on with it and try and get a result.
"We're getting more and more injuries the more we play at the moment and we've got 12 or 13 frontline players who are unavailable so we're getting pretty low on numbers, but we'll get enough right this week and hopefully we'll go into the weekend in a positive mood.
"Just for us to get a result at the moment would be a result, and to be top of the league would certainly lift spirits."
Gloucester: Willie Walker; Iain Balshaw, Henry Trinder, Anthony Allen, James Simpson-Daniel; Olly Barkley, Rory Lawson; Alasdair Dickinson, Olivier Azam (captain), Greg Somerville, Adam Eustace, Alex Brown, Alasdair Strokosch, Apo Satala, Gareth Delve.
Replacements: Andy ***terrell, Nick Wood, Marco Bortolami, Andy Hazell, Dave Lewis, Ryan Lamb, Mark Foster.
London Irish: Delon Armitage; Topsy Ojo, Elvis Seveali'i, Seilala Mapusua, Adam Thompstone; Peter Hewat, Paul Hodgson; Clarke Dermody, David Paice, Tonga Lea'aetoa, Nick Kennedy, Bob Casey (captain), Richard Thorpe, Declan Danaher, Chris Hala'Ufia.
Replacements: Alex Corbisiero, Danie Coetzee, Richard Skuse, James Hudson, Gary Johnson, Alfredo Lalanne, Mike Catt.
From: BBC Sport
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