Quarterback Sam Bradford joined the St Louis Rams as top pick as the leading United States college players were selected in the NFL Draft.
Defensive tackle Ndamukong Suh was taken second by Detroit and offensive lineman Gerald McCoy went to Tampa Bay.
Bradford has yet to sign a contract but last year's top pick earned $40 million (£26m) in a long-term deal.
The shock of the first round was the move by Denver to pick Florida quarterback Tim Tebow 25th overall.
Teams select in reverse order of their final standings to promote competitive balance, handing the Rams, who won just one game in 16 last year, first pick.
The San Francisco 49ers have arrived in London ahead of Sunday's clash with the Denver Broncos at Wembley Stadium.
The 49ers have lost six of their seven games so far this year and blew a late lead as they went down 23-20 to Carolina last weekend.
But head coach Mike Singletary believes the trip to London could turn around his team's ailing season.
"For us, it's a nice chance to get away, regroup and rethink. This has come at a great time for us," he said.
"This week gives us a great opportunity to kind of take a step back and smell the roses a bit and put the pieces in the place that we need to.
"It really works to be a bonus for us. It really gives a chance to kind of get away from the hustle and bustle of the NFL, to come over and kind of think through some things, look at maybe some changes we need to make," said the second-year head coach.
The 49ers could have to do without quarterback Alex Smith who had his non-throwing arm in a sling on Monday after being injured in a third-quarter sack in the defeat by Carolina.
Is this an exhibition or an actual match? If a match, isn't it a bit harsh on the team that lose a home game that season?
Not saying anything bad about the game itself, think it's a great event
Just that home advantage sometimes has a part to play in matches, and i bet the home fans get a bit miffed![]()
A fourth-quarter onslaught by San Francisco gave them a 24-16 win over the Denver Broncos at Wembley Stadium.
A dreary first half saw the 49ers go 3-0 up but Tim Tebow's quarterback sneak gave the Broncos a 7-3 lead.
49ers quarterback Troy Smith came to life in the fourth quarter, running in for a touchdown and completing a 28-yard score to Michael Crabtree.
Frank Gore bundled over the line to extend the lead before Brandon Lloyd's consolation touchdown for the Broncos.
Running back Gore shouldered the burden for the 49ers with 118 yards from 29 carries, while Smith threw 110 of his 196 yards in the exciting final quarter.
It's not that popular in Belgium but the main Franchises that get some attention are: Saints, Raiders, Vikings, Packers, Patriots and Indians.
I support the Raiders and that's it.
I get it, its rugby but far too complicated rules for anybodys liking, players wrapped up & bandaged BEFORE they play, spectators have to play spot the ball, offensive & defensive players tend to be the other team standing on the touch line looking concerned , it'll never catch on here , hopefully .
No, I do not want a NFL shirt for Xmas .
I thankyou .