I played through the first level on Uncharted 2 (the train) and will confess to being thoroughly underwhelmed. Visually it's nice (not stunning, just nice) and the animated cut scenes are excellent, but as a game play experience I found it clunky and unforgiving, a bit like going back to the original Tomb Raider after playing the silky smooth remake.
In the controller front - DualShocks are chuffing horrible things. I bought myself a MadCatz Dualforce 3 along with the PS3, just because it's a good chunky pad with sticks that don't move on their own free will. Plus it also has removable AA batteries instead of a built in rechargeable battery, so it's not as much a pain in the arse when the power runs out.
Still, the only exclusive PS3 titles I've enjoyed are Little Big Planet and Motorstorm. All my other good games for it are available for every other console anyway.