There is two obvious bugs..
The 'Nyanga' bug, which is that for some strange reason this player is hardcoded to injure players. The only way to fix this, i would assume is to edit out the player profile that Nyanga uses, so you could rename him to 'Broken' as the player name and deselect him, just like i've done with Jamie Cudmore. In MUP, it's Thierry Dusaltoir, because he's Nyanga's player profile, renamed. It will make the injury for any team he's selected for, so just make a new Nyanga and edit out the Nyanga you have. That will hopefully fix it.
As for the injury crash, this is an odd one. There is some coding in the game that we haven't found and worked out that controls this kind of thing. But as suggested above, the actual bug is if a player gets injured twice, in it's most likely case. So you can be very observant and sub players for no reason, but then again it probably happens on the opponent as well.. which you can't control. So best to just turn injuries off, or very low and hope. They don't affect the game in anyway whatsoever in any case.
Rather like the high tackle and red card bugs, we haven't figured out the parameters for the coding of the actual rules.