Harlequins go in search of their first Premiership win of the season as they welcome Leicester Tigers to the Stoop in the game of the weekend.
Now coached by former Tigers captain Dean Richards, Quins have been unlucky so far, losing by two points to London Irish before putting up courageous showings against two of the league's top sides - Gloucester and Wasps.
However, one bonus point is all they have to show for their efforts, and they will hope to change that statistic against a Leicester side who have won only once in their opening three encounters.
All the action is live on Sky Sports 2 from 6pm.
Also on Saturday, Bath entertain Worcester Warriors while Gloucester host Northampton Saints.
Bath are notoriously strong on their own patch, as shown in their recent 43-25 win over Leicester, and the Warriors will have their work cut out if they are to move off the bottom.
Saints meanwhile lie just a point behind Gloucester, who are yet to be defeated this season.
The weekend kicks off with a cracker from Edgeley Park, where champions Sale Sharks welcome Saracens.
The fixture could see former rugby league colleagues Jason Robinson and Andy Farrell grace the same pitch for the first time since their playing days at Wigan Warriors.
Defeat for either side would allow London Irish or Newcastle Falcons to leapfrog them in the other Friday encounter.
High-flying Bristol wrap up the weekend's action at home to Wasps, in a fixture that brings together two of the league's undefeated sides.
Wasps have a 100 percent record so far, but they only managed a 9-9 draw at the Memorial last season, and Richard Hill's men will be determined to repeat the feat on Sunday.
Click below for team news from each game:
Friday Sale Sharks 19.45 Saracens
Newcastle Falcons 20.00 London Irish
Bath 14.15 Worcester Warriors
Gloucester 15.00 Northampton Saints
18.15 Leicester Tigers
Bristol 15.00 Wasps